The Wnt gene family in tumorigenesis and in normal development
R Nusse - The Journal of steroid biochemistry and molecular …, 1992 - Elsevier
The Journal of steroid biochemistry and molecular biology, 1992•Elsevier
Various members of the Wnt gene family have been identified as activated oncogenes in
mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt
gene, and clonal variation when those tumors are transplanted to become hormone-
independent. The normal function of many Wnt genes is to control pattern formation in early
embryos, as shown by expression profiles and by mutant analysis.
mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt
gene, and clonal variation when those tumors are transplanted to become hormone-
independent. The normal function of many Wnt genes is to control pattern formation in early
embryos, as shown by expression profiles and by mutant analysis.
Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis.
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