[HTML][HTML] Differential regulation of the actomyosin interaction by skeletal and cardiac troponin isoforms
R Maytum, B Westerdorf, K Jaquet… - Journal of Biological …, 2003 - ASBMB
There are significant isoform differences between the skeletal and cardiac troponin
complexes. Studies of the regulatory properties of these proteins have previously shown
only significant differences in the calcium dependence of their regulation. Using a sensitive
myosin subfragment 1 (S1) binding assay we show that in the presence of calcium, thin
filaments reconstituted with either skeletal or cardiac troponin produce virtually identical S1
binding curves. However in the absence of calcium the S1 binding curves differ …
complexes. Studies of the regulatory properties of these proteins have previously shown
only significant differences in the calcium dependence of their regulation. Using a sensitive
myosin subfragment 1 (S1) binding assay we show that in the presence of calcium, thin
filaments reconstituted with either skeletal or cardiac troponin produce virtually identical S1
binding curves. However in the absence of calcium the S1 binding curves differ …