Dendritic cells shuttle microbes across gut epithelial monolayers
M Rescigno, G Rotta, B Valzasina… - Immunobiology, 2001 - Elsevier
Understanding the mechanisms governing the type of induced immune response after
microbial invasion, could be of crucial importance for the rational design of a bacteria-based
vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most
powerful antigen presenting cells, could be extremely effective. Here we describe that
CD11b+ CD8a− dendritic cells are involved in the direct bacterial uptake across mucosal
surfaces. DCs are widely spread in the lamina propria of the gut and are recruited at the site …
microbial invasion, could be of crucial importance for the rational design of a bacteria-based
vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most
powerful antigen presenting cells, could be extremely effective. Here we describe that
CD11b+ CD8a− dendritic cells are involved in the direct bacterial uptake across mucosal
surfaces. DCs are widely spread in the lamina propria of the gut and are recruited at the site …