Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin
JL Erwin, LM DaSilva, S Bavari, SF Little… - Infection and …, 2001 - Am Soc Microbiol
JL Erwin, LM DaSilva, S Bavari, SF Little, AM Friedlander, TC Chanh
Infection and immunity, 2001•Am Soc MicrobiolWe present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces
proinflammatory cytokine production in macrophages. Suppression is observed with
extremely low levels of LT and involves inhibition of transcription of cytokine messenger
RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory
response.
proinflammatory cytokine production in macrophages. Suppression is observed with
extremely low levels of LT and involves inhibition of transcription of cytokine messenger
RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory
response.
Abstract
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.
American Society for Microbiology