[HTML][HTML] Cloning and characterization of the promoters of the maxiK channel α and β subunits
PDK Dhulipala, MI Kotlikoff - Biochimica et Biophysica Acta (BBA)-Gene …, 1999 - Elsevier
Large conductance, calcium-activated potassium (maxiK) channels are expressed in nerve,
muscle, and other cell types and are important determinants of smooth muscle tone. To
determine the mechanisms involved in the transcriptional regulation of maxiK channels, we
characterized the promoter regions of the pore forming (α) and regulatory (β) subunits of the
human channel complex. Maximum promoter activity (up to 12.3-fold over control) occurred
between nucleotides− 567 and− 220 for the α subunit (hSlo) gene. The minimal promoter is …
muscle, and other cell types and are important determinants of smooth muscle tone. To
determine the mechanisms involved in the transcriptional regulation of maxiK channels, we
characterized the promoter regions of the pore forming (α) and regulatory (β) subunits of the
human channel complex. Maximum promoter activity (up to 12.3-fold over control) occurred
between nucleotides− 567 and− 220 for the α subunit (hSlo) gene. The minimal promoter is …