[HTML][HTML] The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity
LS Tobacman, M Nihli, C Butters, M Heller… - Journal of Biological …, 2002 - ASBMB
In cardiac and skeletal muscles tropomyosin binds to the actin outer domain in the absence
of Ca 2+, and in this position tropomyosin inhibits muscle contraction by interfering sterically
with myosin-actin binding. The globular domain of troponin is believed to produce this B-
state of the thin filament (Lehman, W., Hatch, V., Korman, VL, Rosol, M., Thomas, LT,
Maytum, R., Geeves, MA, Van Eyk, JE, Tobacman, LS, and Craig, R.(2000) J. Mol. Biol. 302,
593–606) via troponin I-actin interactions that constrain the tropomyosin. The present study …
of Ca 2+, and in this position tropomyosin inhibits muscle contraction by interfering sterically
with myosin-actin binding. The globular domain of troponin is believed to produce this B-
state of the thin filament (Lehman, W., Hatch, V., Korman, VL, Rosol, M., Thomas, LT,
Maytum, R., Geeves, MA, Van Eyk, JE, Tobacman, LS, and Craig, R.(2000) J. Mol. Biol. 302,
593–606) via troponin I-actin interactions that constrain the tropomyosin. The present study …