[HTML][HTML] Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass
LC Gowen, DN Petersen, AL Mansolf, H Qi… - Journal of Biological …, 2003 - ASBMB
We have previously described osteoblast/osteocyte factor 45 (OF45), a novel bone-specific
extracellular matrix protein, and demonstrated that its expression is tightly linked to
mineralization and bone formation. In this report, we have cloned and characterized the
mouse OF45 cDNA and genomic region. Mouse OF45 (also called MEPE) was similar to its
rat orthologue in that its expression was increased during mineralization in osteoblast
cultures and the protein was highly expressed within the osteocytes that are imbedded …
extracellular matrix protein, and demonstrated that its expression is tightly linked to
mineralization and bone formation. In this report, we have cloned and characterized the
mouse OF45 cDNA and genomic region. Mouse OF45 (also called MEPE) was similar to its
rat orthologue in that its expression was increased during mineralization in osteoblast
cultures and the protein was highly expressed within the osteocytes that are imbedded …