Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
DDG Despriet, CCW Klaver, JCM Witteman… - Jama, 2006 - jamanetwork.com
ContextThe evidence that inflammation is an important pathway in age-related macular
degeneration (AMD) is growing. Recent case-control studies demonstrated an association
between the complement factor H (CFH) gene, a regulator of complement, and AMD.
ObjectivesTo assess the associations between the CFH gene and AMD in the general
population and to investigate the modifying effect of smoking, serum inflammatory markers,
and genetic variation of C-reactive protein (CRP). Design, Setting, and …
degeneration (AMD) is growing. Recent case-control studies demonstrated an association
between the complement factor H (CFH) gene, a regulator of complement, and AMD.
ObjectivesTo assess the associations between the CFH gene and AMD in the general
population and to investigate the modifying effect of smoking, serum inflammatory markers,
and genetic variation of C-reactive protein (CRP). Design, Setting, and …