Staphylococcal exoproducts down-regulate cyclooxygenase 1 and 2 in peritoneal macrophages
RK Mackenzie, N Topley, A Neubauer, GA Coles… - Journal of Laboratory …, 1997 - Elsevier
Peritoneal macrophages (PMØs) are important components of the host defense against
microbial infection in patients undergoing continuous ambulatory peritoneal dialysis
(CAPD). Incubation of human PM⊘ s with cell-free supernatant (BFS), prepared from
Staphylococcus aureus, inhibited prostaglandin E2 (PGE2) and thromboxane B2 (TXB2)
production. Slot-blot analysis of cyclooxygenase-1 (Cox-1) and Cox-2 demonstrated a
decrease in both Cox-1 (29%) and, to a greater extent, Cox-2 (65%) protein expression after …
microbial infection in patients undergoing continuous ambulatory peritoneal dialysis
(CAPD). Incubation of human PM⊘ s with cell-free supernatant (BFS), prepared from
Staphylococcus aureus, inhibited prostaglandin E2 (PGE2) and thromboxane B2 (TXB2)
production. Slot-blot analysis of cyclooxygenase-1 (Cox-1) and Cox-2 demonstrated a
decrease in both Cox-1 (29%) and, to a greater extent, Cox-2 (65%) protein expression after …