[HTML][HTML] Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells
S Kannan, M De Santis, M Lohmeyer, J David… - Journal of Biological …, 1997 - ASBMB
Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family,
was found to interact with a high affinity, saturable binding site (s) on HC-11 mouse
mammary epithelial cells and on several different human breast cancer cell lines. This
receptor exhibits specificity for CR-1, since other EGF-related peptides including EGF,
transforming growth factor α, heparin-binding EGF-like growth factor, amphiregulin,
epiregulin, betacellulin, or heregulin β1 that bind to either the EGF receptor or to other type 1 …
was found to interact with a high affinity, saturable binding site (s) on HC-11 mouse
mammary epithelial cells and on several different human breast cancer cell lines. This
receptor exhibits specificity for CR-1, since other EGF-related peptides including EGF,
transforming growth factor α, heparin-binding EGF-like growth factor, amphiregulin,
epiregulin, betacellulin, or heregulin β1 that bind to either the EGF receptor or to other type 1 …