Gram-negative sepsis remains an urgent medical problem, with more than 200,000 cases
occurring each year in the United States and an associated mortality rate of 20 to 50 percent.
Since the onset of shock greatly worsens prognosis and to encourage early intervention, the
term sepsis syndrome was developed to describe the features of a preshock septic state.
Early clinical and metabolic indicators are discussed, and current therapy is reviewed. Better
understanding of the pathophysiology of endotoxin release from Gram-negative bacteria …