SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12
MH Meisler, LL Barrow, CM Canessa, BC Rossier - Genomics, 1994 - Elsevier
MH Meisler, LL Barrow, CM Canessa, BC Rossier
Genomics, 1994•ElsevierSCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat
colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human
SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse
SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed
order of mouse genes was centromere-Raf1-(2.1±2.1)-Scnn1, Vwf-(1.9±1.9)-Ntf3, with 0/101
recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected …
colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human
SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse
SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed
order of mouse genes was centromere-Raf1-(2.1±2.1)-Scnn1, Vwf-(1.9±1.9)-Ntf3, with 0/101
recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected …
Abstract
SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 ± 2.1)-Scnn1, Vwf -(1.9 ± 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt).
Elsevier