Interferons as a paradigm for cytokine signal transduction
C Schindler, S Brutsaert - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
C Schindler, S Brutsaert
Cellular and Molecular Life Sciences CMLS, 1999•SpringerCharacterization of the ability of interferons to induce immediate early genes led to the
identification of the signal transducer and activators of transcription (STAT) signaling
paradigm, where a single protein transduces signals directly from the receptor to the
nucleus. Subsequent studies have determined that all cytokines transduce pivotal signals
through at least one of the seven members of this STAT family. Notably, cytokines can be
placed in functional subgroups based on the STATs they activate.
identification of the signal transducer and activators of transcription (STAT) signaling
paradigm, where a single protein transduces signals directly from the receptor to the
nucleus. Subsequent studies have determined that all cytokines transduce pivotal signals
through at least one of the seven members of this STAT family. Notably, cytokines can be
placed in functional subgroups based on the STATs they activate.
Abstract
Characterization of the ability of interferons to induce immediate early genes led to the identification of the signal transducer and activators of transcription (STAT) signaling paradigm, where a single protein transduces signals directly from the receptor to the nucleus. Subsequent studies have determined that all cytokines transduce pivotal signals through at least one of the seven members of this STAT family. Notably, cytokines can be placed in functional subgroups based on the STATs they activate.
Springer