Targeted CNS expression of interferon-γ in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development
JG Corbin, D Kelly, EM Rath, KD Baerwald… - Molecular and Cellular …, 1996 - Elsevier
Circumstantial and experimental evidence has implicated the immune cytokine interferon-
gamma (IFN-γ) as a key mediator in the pathological changes that are observed in many
demyelinating disorders, including the most common human demyelinating disease,
multiple sclerosis. To produce an animal model with which to study the effects of IFN-γ on
the CNS, we have generated transgenic mice in which the expression of IFN-γ has been
placed under the transcriptional control of the myelin basic protein (MBP) gene. Transgenic …
gamma (IFN-γ) as a key mediator in the pathological changes that are observed in many
demyelinating disorders, including the most common human demyelinating disease,
multiple sclerosis. To produce an animal model with which to study the effects of IFN-γ on
the CNS, we have generated transgenic mice in which the expression of IFN-γ has been
placed under the transcriptional control of the myelin basic protein (MBP) gene. Transgenic …