[PDF][PDF] Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
TY Nakagawa, WH Brissette, PD Lira, RJ Griffiths… - Immunity, 1999 - cell.com
TY Nakagawa, WH Brissette, PD Lira, RJ Griffiths, N Petrushova, J Stock, JD McNeish…
Immunity, 1999•cell.comCathepsins have been implicated in the degradation of proteins destined for the MHC class
II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator
of MHC class II function. Mice lacking the lysosomal cysteine proteinase cathepsin S (catS)
demonstrated a profound inhibition of Ii degradation in professional APC in vivo. A marked
variation in the generation of MHC class II-bound Ii fragments and presentation of
exogenous proteins was observed between B cells, dendritic cells, and macrophages …
II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator
of MHC class II function. Mice lacking the lysosomal cysteine proteinase cathepsin S (catS)
demonstrated a profound inhibition of Ii degradation in professional APC in vivo. A marked
variation in the generation of MHC class II-bound Ii fragments and presentation of
exogenous proteins was observed between B cells, dendritic cells, and macrophages …
Abstract
Cathepsins have been implicated in the degradation of proteins destined for the MHC class II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator of MHC class II function. Mice lacking the lysosomal cysteine proteinase cathepsin S (catS) demonstrated a profound inhibition of Ii degradation in professional APC in vivo. A marked variation in the generation of MHC class II-bound Ii fragments and presentation of exogenous proteins was observed between B cells, dendritic cells, and macrophages lacking catS. CatS-deficient mice showed diminished susceptibility to collagen-induced arthritis, suggesting a potential therapeutic target for regulation of immune responsiveness.
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