[HTML][HTML] Nodal signaling uses activin and transforming growth factor-β receptor-regulated Smads
A Kumar, V Novoselov, AJ Celeste, NM Wolfman… - Journal of Biological …, 2001 - ASBMB
Nodal, a member of the transforming growth factor β (TGF-β) superfamily, is implicated in
many events critical to the early vertebrate embryo, including mesoderm formation, anterior
patterning, and left-right axis specification. Here we define the intracellular signaling
pathway induced by recombinant nodal protein treatment of P19 embryonal carcinoma cells.
Nodal signaling activates pAR3-Lux, a luciferase reporter previously shown to respond
specifically to activin and TGF-β. However, nodal is unable to induce pTlx2-Lux, a reporter …
many events critical to the early vertebrate embryo, including mesoderm formation, anterior
patterning, and left-right axis specification. Here we define the intracellular signaling
pathway induced by recombinant nodal protein treatment of P19 embryonal carcinoma cells.
Nodal signaling activates pAR3-Lux, a luciferase reporter previously shown to respond
specifically to activin and TGF-β. However, nodal is unable to induce pTlx2-Lux, a reporter …