[HTML][HTML] Formation of triple-stranded DNA at d (GA· TC) n sequences prevents nucleosome assembly and is hindered by nucleosomes
ML Espinás, E Jiménez-García… - Journal of Biological …, 1996 - ASBMB
Simple repeating d (GA· TC) n DNA sequences are frequently found at eukaryotic promoters,
and in some cases they have been shown to be nucleosome free in vivo. These sequences
show a high degree of structural polymorphism and are capable of adopting several types of
non-B-DNA conformations. Here we show that the structural versatility of these sequences
affects their ability to be packed into nucleosomes. Nucleosome assembly onto short double-
stranded DNA fragments carrying d (GA· TC) n sequences of different length (n= 10 and n …
and in some cases they have been shown to be nucleosome free in vivo. These sequences
show a high degree of structural polymorphism and are capable of adopting several types of
non-B-DNA conformations. Here we show that the structural versatility of these sequences
affects their ability to be packed into nucleosomes. Nucleosome assembly onto short double-
stranded DNA fragments carrying d (GA· TC) n sequences of different length (n= 10 and n …