Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement
HS Shin, R Snyderman, E Friedman, A Mellors… - Science, 1968 - science.org
HS Shin, R Snyderman, E Friedman, A Mellors, MM Mayer
Science, 1968•science.orgThe fifth component of guinea pig complement, with a sedimentation coefficient 7.8 S, is
cleaved by sensitized sheep erythrocytes treated with the first four components of
complement into two fragments with sedimentation coefficients of 7.4 S and 1.5 S. The
smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity
for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig
ileum.
cleaved by sensitized sheep erythrocytes treated with the first four components of
complement into two fragments with sedimentation coefficients of 7.4 S and 1.5 S. The
smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity
for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig
ileum.
The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.
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