SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset
J Simiand, M Keane, PE Keane… - Behavioural …, 1998 - journals.lww.com
Abstract SR 141716 (1 and 3 mg/kg po), a selective central (CB1) cannabinoid receptor
antagonist, selectively reduced feeding of a very highly palatable cane-sugar mixture in
marmosets. In contrast, standard primate pellet intake was not modified at the lower dose,
but was slightly increased (+ 29%; p< 0.01) by the higher dose of SR 141716. These results
are in agreement with the hypothesis that endogenous cannabinoid systems are involved in
the modulation of the appetitive value of food. Behav Pharmacol 9: 179-181© 1998 Rapid …
antagonist, selectively reduced feeding of a very highly palatable cane-sugar mixture in
marmosets. In contrast, standard primate pellet intake was not modified at the lower dose,
but was slightly increased (+ 29%; p< 0.01) by the higher dose of SR 141716. These results
are in agreement with the hypothesis that endogenous cannabinoid systems are involved in
the modulation of the appetitive value of food. Behav Pharmacol 9: 179-181© 1998 Rapid …