[HTML][HTML] Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells
HL Weiner - Microbes and infection, 2001 - Elsevier
Oral tolerance is a long recognized method to induce peripheral immune tolerance. Oral
tolerance has been used successfully to treat animal models of autoimmune diseases and is
being tested in human diseases. Low doses of oral antigen induce active suppression,
whereas high doses induce clonal anergy and deletion. Oral antigen preferentially
generates a Th2 (IL-4/IL-10)-or a Th3 (TGF-β)-type response. Th3-type cells are a unique T-
cell subset which primarily secrete TGF-β, provide help for IgA and have suppressive …
tolerance has been used successfully to treat animal models of autoimmune diseases and is
being tested in human diseases. Low doses of oral antigen induce active suppression,
whereas high doses induce clonal anergy and deletion. Oral antigen preferentially
generates a Th2 (IL-4/IL-10)-or a Th3 (TGF-β)-type response. Th3-type cells are a unique T-
cell subset which primarily secrete TGF-β, provide help for IgA and have suppressive …