Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2, 8-diazaspiro [4.5] decanes
MM Mehrotra, JA Heath, JW Rose, MS Smyth… - Bioorganic & medicinal …, 2002 - Elsevier
MM Mehrotra, JA Heath, JW Rose, MS Smyth, J Seroogy, DL Volkots, G Ruhter, T Schotten…
Bioorganic & medicinal chemistry letters, 2002•ElsevierThe synthesis and biological activity of analogues containing spiro piperidinylpyridine and
pyrrolidinylpyridine templates are described. The potent activity of these compounds as
platelet aggregation inhibitors demonstrates the utility of the spiro structures as central
template for nonpeptide RGD mimics.
pyrrolidinylpyridine templates are described. The potent activity of these compounds as
platelet aggregation inhibitors demonstrates the utility of the spiro structures as central
template for nonpeptide RGD mimics.
The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics.
Elsevier