[CITATION][C] Type 1 plasminogen activator inhibitor
L DJ - Progress in hemostasis and thrombosis, 1988 - cir.nii.ac.jp
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.
RR Schleef, MP Bevilacqua, M Sawdey… - Journal of Biological …, 1988 - Elsevier
Regulation of the fibrinolytic system of cultured human umbilical vein endothelial cells
(HUVECs) by recombinant interleukin 1 beta (rIL-1 beta) and tumor necrosis factor alpha
(rTNF alpha) was investigated. Functional and immunologic assays indicated that both
cytokines decreased HUVEC tissue-type plasminogen activator (tPA) and increased type 1
plasminogen activator inhibitor (PAI-1) in a dose-and time-dependent manner. Maximal
effects (50% decrease in tPA antigen; 300-400% increase in PAI-1 activity) were achieved …
(HUVECs) by recombinant interleukin 1 beta (rIL-1 beta) and tumor necrosis factor alpha
(rTNF alpha) was investigated. Functional and immunologic assays indicated that both
cytokines decreased HUVEC tissue-type plasminogen activator (tPA) and increased type 1
plasminogen activator inhibitor (PAI-1) in a dose-and time-dependent manner. Maximal
effects (50% decrease in tPA antigen; 300-400% increase in PAI-1 activity) were achieved …