[HTML][HTML] Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1
S Stefansson, E Petitclerc, MKK Wong… - Journal of Biological …, 2001 - ASBMB
The process of angiogenesis is important in both normal and pathologic physiology.
However, the mechanisms whereby factors such as basic fibroblast growth factor promote
the formation of new blood vessels are not known. In the present study, we demonstrate that
exogenously added plasminogen activator inhibitor-1 (PAI-1) at therapeutic concentrations
is a potent inhibitor of basic fibroblast growth factor-induced angiogenesis in the chicken
chorioallantoic membrane. By using specific PAI-1 mutants with either their vitronectin …
However, the mechanisms whereby factors such as basic fibroblast growth factor promote
the formation of new blood vessels are not known. In the present study, we demonstrate that
exogenously added plasminogen activator inhibitor-1 (PAI-1) at therapeutic concentrations
is a potent inhibitor of basic fibroblast growth factor-induced angiogenesis in the chicken
chorioallantoic membrane. By using specific PAI-1 mutants with either their vitronectin …