[HTML][HTML] Oxidation of Low Density Lipoproteins Greatly Enhances Their Association with Lipoprotein Lipase Anchored to Endothelial Cell Matrix (∗)
BJ Auerbach, CL Bisgaier, J Wölle, U Saxena - Journal of Biological …, 1996 - ASBMB
Native and oxidized low density lipoprotein retention within arterial wall endothelial cell
matrix (ECM) is an early event in the pathogenesis of atherosclerosis. Previously we showed
lipoprotein lipase (LPL) addition to ECM enhanced the retention of apoB-containing
lipoproteins. In the present studies we examined whether the oxidation of low density
lipoprotein (LDL) increases its retention by LPL-containing ECM. Except where noted, 125 I-
labeled moderately oxidized LDL (ModOxLDL) was prepared by long term storage of 125 I …
matrix (ECM) is an early event in the pathogenesis of atherosclerosis. Previously we showed
lipoprotein lipase (LPL) addition to ECM enhanced the retention of apoB-containing
lipoproteins. In the present studies we examined whether the oxidation of low density
lipoprotein (LDL) increases its retention by LPL-containing ECM. Except where noted, 125 I-
labeled moderately oxidized LDL (ModOxLDL) was prepared by long term storage of 125 I …