The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by macrophages.

P Lindqvist, AM Ostlund-Lindqvist, JL Witztum… - Journal of Biological …, 1983 - ASBMB
We have previously shown that cultured macrophages secrete lipoprotein lipase (LPL) into
the culture medium. The purpose of these experiments was to determine the role of LPL in
the uptake of very low density lipoproteins (VLDL). Both J774 cells and mouse peritoneal
macrophages took up and degraded normotriglyceridemic VLDL in a saturable manner.
Uptake of VLDL was effectively competed for by rabbit beta-VLDL, human VLDL, but not by
native LDL or acetyl LDL. LPL activity accelerated saturable uptake of VLDL but was not a …