Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.
M Aviram, EL Bierman, A Chait - Journal of Biological Chemistry, 1988 - ASBMB
Incubation of low density lipoprotein (s)(LDL) with either lipoprotein lipase or hepatic lipase
led to modification of the core lipid composition of LDL. Both lipases modified LDL by
substantially reducing core triglyceride content without producing marked differences in size,
charge, or lipid peroxide content in comparison to native LDL. The triglyceride-depleted
forms of LDL that result from treatment with these two enzymes were degraded at
approximately twice the rate of native LDL by human monocyte-derived macrophages …
led to modification of the core lipid composition of LDL. Both lipases modified LDL by
substantially reducing core triglyceride content without producing marked differences in size,
charge, or lipid peroxide content in comparison to native LDL. The triglyceride-depleted
forms of LDL that result from treatment with these two enzymes were degraded at
approximately twice the rate of native LDL by human monocyte-derived macrophages …