[HTML][HTML] Structural basis of calcification inhibition by α2-HS glycoprotein/fetuin-A: formation of colloidal calciprotein particles
A Heiss, A DuChesne, B Denecke, J Grotzinger… - Journal of Biological …, 2003 - ASBMB
Genetic evidence from mutant mice suggests that α 2-HS glycoprotein/fetuin-A (Ahsg) is a
systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted
calcification. Using electron microscopy and dynamic light scattering, we demonstrate that
precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal
spheres, containing Ahsg, calcium, and phosphate. These" calciprotein particles" of 30–150
nm in diameter are initially amorphous and soluble but turn progressively more crystalline …
systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted
calcification. Using electron microscopy and dynamic light scattering, we demonstrate that
precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal
spheres, containing Ahsg, calcium, and phosphate. These" calciprotein particles" of 30–150
nm in diameter are initially amorphous and soluble but turn progressively more crystalline …