Regulation and function of adenosine deaminase in mice
MR Blackburn, RE Kellems - Progress in nucleic acid research and …, 1996 - Elsevier
Publisher Summary Adenosine deaminase (ADA) is an essential and widely distributed
enzyme of purine catabolism that catalyzes the hydrolytic deamination of adenosine and
deoxyadenosine to inosine and deoxyinosine. The catalytic moiety of ADA exists as a single
polypeptide chain, with approximately 83.1% amino-acid sequence identity between
humans and mice. Recombinant murine ADA has been subjected to crystallographic
analysis and the architecture of the enzyme is a parallel α/β barrel with eight central β …
enzyme of purine catabolism that catalyzes the hydrolytic deamination of adenosine and
deoxyadenosine to inosine and deoxyinosine. The catalytic moiety of ADA exists as a single
polypeptide chain, with approximately 83.1% amino-acid sequence identity between
humans and mice. Recombinant murine ADA has been subjected to crystallographic
analysis and the architecture of the enzyme is a parallel α/β barrel with eight central β …