Chronic delta hepatitis is a severe disease with a rapidly progressive course for which
currently no effective treatment exists. Treatment with α-interferon (α-IFN) can inhibit HDV
replication and improve serum chemistries in a number of patients. Meta-analysis of five
randomized controlled trials using at least 5 MU/m 2 of α-IFN tiw for a minimum of 3 months
showed that α-IFN had a statistically significant effect in normalizing ALT values during
therapy at ap level of< 0.001, with a 10.24 odds ratio and a 28.69% risk difference (Mantel …