Protein prenylation: genes, enzymes, targets, and functions
WR Schafer, J Rine - Annual review of genetics, 1992 - annualreviews.org
Annual review of genetics, 1992•annualreviews.org
The regulation, functional activation, and intracellular targeting of biological macromolecules
are often mediated through the covalent attachment of specific chemical moieties. The
posttranslational modification of specific proteins by phosphorylation, glycosylation,
acetylation, fatty acylation, and methylation has been studied extensively, and a variety of
critical biological functions have been ascribed to these particular side groups. In contrast to
these familiar types of chemical modification, protein prenylation is a process
are often mediated through the covalent attachment of specific chemical moieties. The
posttranslational modification of specific proteins by phosphorylation, glycosylation,
acetylation, fatty acylation, and methylation has been studied extensively, and a variety of
critical biological functions have been ascribed to these particular side groups. In contrast to
these familiar types of chemical modification, protein prenylation is a process
The regulation, functional activation, and intracellular targeting of biological macromolecules are often mediated through the covalent attachment of specific chemical moieties. The posttranslational modification of specific proteins by phosphorylation, glycosylation, acetylation, fatty acylation, and methylation has been studied extensively, and a variety of critical biological functions have been ascribed to these particular side groups. In contrast to these familiar types of chemical modification, protein prenylation is a process
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