[HTML][HTML] Identification and characterization of a novel cytokine, THANK, aTNF homologue that ActivatesApoptosis, nuclear factor-κB, and c-Jun NH2-terminal kinase
A Mukhopadhyay, J Ni, Y Zhai, GL Yu… - Journal of Biological …, 1999 - ASBMB
By using the amino acid sequence motif of tumor necrosis factor (TNF), we searched the
expressed sequence tag data base and identified a novel full-length cDNA encoding 285
amino acid residues and named it THANK. THANK is a type II transmembrane protein with
15–20% overall amino acid sequence homology to TNF, LT-α, FasL, and LIGHT, all
members of the TNF family. The mRNA for THANK was expressed at high levels by
peripheral blood leukocytes, lymph node, spleen, and thymus and at low levels by small …
expressed sequence tag data base and identified a novel full-length cDNA encoding 285
amino acid residues and named it THANK. THANK is a type II transmembrane protein with
15–20% overall amino acid sequence homology to TNF, LT-α, FasL, and LIGHT, all
members of the TNF family. The mRNA for THANK was expressed at high levels by
peripheral blood leukocytes, lymph node, spleen, and thymus and at low levels by small …