Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis
YCQ Zang, J Hong, MV Tejada‐Simon… - European journal of …, 2000 - Wiley Online Library
YCQ Zang, J Hong, MV Tejada‐Simon, S Li, VM Rivera, JM Killian, JZ Zhang
European journal of immunology, 2000•Wiley Online LibraryT cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis
of multiple sclerosis (MS). In this study, we demonstrated that subcutaneous inoculations
with irradiated autologous MBP‐reactive T cell clones (T cell vaccination) elicited CD8+
antiidiotypic T cell responses and CD4+ Th2 cell responses in patients with MS. Both
regulatory cell types induced by T cell vaccination contributed to the inhibition of MBP‐
reactive T cells while they differed in the recognition pattern and functional properties. We …
of multiple sclerosis (MS). In this study, we demonstrated that subcutaneous inoculations
with irradiated autologous MBP‐reactive T cell clones (T cell vaccination) elicited CD8+
antiidiotypic T cell responses and CD4+ Th2 cell responses in patients with MS. Both
regulatory cell types induced by T cell vaccination contributed to the inhibition of MBP‐
reactive T cells while they differed in the recognition pattern and functional properties. We …
Abstract
T cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis of multiple sclerosis (MS). In this study, we demonstrated that subcutaneous inoculations with irradiated autologous MBP‐reactive T cell clones (T cell vaccination) elicited CD8+ antiidiotypic T cell responses and CD4+ Th2 cell responses in patients with MS. Both regulatory cell types induced by T cell vaccination contributed to the inhibition of MBP‐reactive T cells while they differed in the recognition pattern and functional properties. We describe for the first time that the Th2 regulatory cells reacted with activated but not resting T cells in the context of MHC class II molecules and inhibited the proliferation of MBP‐reactive T cells through the secretion of IL‐4 and IL‐10. The T‐T cell interaction mediated by Th2 regulatory cells was independent of the antigen specificity of activated T cells. The findings have important implications for our understanding of the regulatory mechanism induced by T cell vaccination.
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