Evidence in vivo showing increase of baseline nitric oxide generation and impairment of endothelium-dependent vasodilation in normotensive patients on chronic …

J Passauer, E Büssemaker, U Range… - Journal of the …, 2000 - journals.lww.com
Cardiovascular mortality is excessive in hemodialyzed patients. Observations in
atherosclerosis suggest that endothelial dysfunction and impaired nitric oxide (NO) may be
involved. However, the relation of endothelial NO to its vascular effects has not been studied
conclusively in uremia. Therefore, to study these questions an invasive technique was used
in normotensive patients who were on hemodialysis (HD; n= 11) and in matched control
subjects (n= 11). Pharmacologic agents were infused into the brachial artery to test the chain …