[HTML][HTML] Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice
A Valujskikh, B Pantenburg, PS Heeger - American Journal of …, 2002 - Elsevier
Costimulatory blockade can induce long‐term allograft survival in naļve animals, but may
not be as effective in animals with previously primed immune repertoires. We attempted to
induce long‐term graft survival in B10. D2 recipients of B10. A cardiac allografts using donor‐
specific transfusion (DST) plus anti‐CD40 ligand antibody (αCD40L). Recipients were either
naļve mice, or mice previously primed to B10. A or third party alloantigens through
engraftment and rejection of skin transplants. Untreated naļve mice rejected cardiac …
not be as effective in animals with previously primed immune repertoires. We attempted to
induce long‐term graft survival in B10. D2 recipients of B10. A cardiac allografts using donor‐
specific transfusion (DST) plus anti‐CD40 ligand antibody (αCD40L). Recipients were either
naļve mice, or mice previously primed to B10. A or third party alloantigens through
engraftment and rejection of skin transplants. Untreated naļve mice rejected cardiac …