Growth in the Presence of Salicylate Increases Fluoroquinolone Resistance in Staphylococcus aureus

JE Gustafson, PV Candelaria, SA Fisher… - Antimicrobial Agents …, 1999 - Am Soc Microbiol
JE Gustafson, PV Candelaria, SA Fisher, JP Goodridge, TM Lichocik, TM McWilliams…
Antimicrobial Agents and Chemotherapy, 1999Am Soc Microbiol
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-
susceptible and-resistant Staphylococcus aureus. Salicylate allowed a greater number of
cells from ciprofloxacin-susceptible and-resistant strains to survive on high fluoroquinolone
concentrations. Salicylate also increased the frequency with which a susceptible strain
mutated to become more resistant to ciprofloxacin.
Abstract
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistantStaphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.
American Society for Microbiology