Growth in the Presence of Salicylate Increases Fluoroquinolone Resistance in Staphylococcus aureus
Antimicrobial Agents and Chemotherapy, 1999•Am Soc Microbiol
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-
susceptible and-resistant Staphylococcus aureus. Salicylate allowed a greater number of
cells from ciprofloxacin-susceptible and-resistant strains to survive on high fluoroquinolone
concentrations. Salicylate also increased the frequency with which a susceptible strain
mutated to become more resistant to ciprofloxacin.
susceptible and-resistant Staphylococcus aureus. Salicylate allowed a greater number of
cells from ciprofloxacin-susceptible and-resistant strains to survive on high fluoroquinolone
concentrations. Salicylate also increased the frequency with which a susceptible strain
mutated to become more resistant to ciprofloxacin.
Abstract
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistantStaphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.
American Society for Microbiology