[HTML][HTML] Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis
JEB Reusch, DJ Klemm - Journal of Biological Chemistry, 2002 - ASBMB
White adipose tissue mass is governed by competing processes that control lipid synthesis
and storage, the development of new adipocytes, and their survival. We have shown that the
transcription factor cAMP-response element-binding protein (CREB) participates in
adipogenesis, with constitutively active forms of CREB inducing adipocyte differentiation and
dominant negative forms of CREB blocking this process. In other cell types, CREB and
related factors have been shown to play important roles in survival and apoptosis. Here we …
and storage, the development of new adipocytes, and their survival. We have shown that the
transcription factor cAMP-response element-binding protein (CREB) participates in
adipogenesis, with constitutively active forms of CREB inducing adipocyte differentiation and
dominant negative forms of CREB blocking this process. In other cell types, CREB and
related factors have been shown to play important roles in survival and apoptosis. Here we …