Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo
VO Mallet, C Mitchell, E Mezey, M Fabre, JE Guidotti… - Hepatology, 2002 - Elsevier
Cell-based therapy may some day be a therapeutic alternative to liver transplantation.
Recent observations indicating that hematopoietic stem cells can differentiate into
hepatocytes have opened new therapeutic prospects. However, the clinical relevance of this
phenomenon is unknown. We have previously developed a strategy based on the protective
effect of Bcl-2 against Fas-mediated apoptosis to selectively amplify a small number of
hepatocytes in vivo. We now show that this approach can be used to amplify a minor …
Recent observations indicating that hematopoietic stem cells can differentiate into
hepatocytes have opened new therapeutic prospects. However, the clinical relevance of this
phenomenon is unknown. We have previously developed a strategy based on the protective
effect of Bcl-2 against Fas-mediated apoptosis to selectively amplify a small number of
hepatocytes in vivo. We now show that this approach can be used to amplify a minor …