Endotoxin (ET) induces neutrophil sequestration in hepatic sinusoids, the activation of
proinflammatory transcription factors (nuclear factor κB [NF-κB]) with up-regulation of
adhesion molecules on sinusoidal endothelial cells and hepatocytes. However, if
galactosamine (Gal) is co-administered with ET, neutrophils transmigrate and attack
parenchymal cells. This suggests that a signal from parenchymal cells triggers neutrophil
transmigration. In this study, we tested the hypothesis that parenchymal cell apoptosis may …