NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
S Chitturi, S Abeygunasekera, GC Farrell… - Hepatology, 2002 - Elsevier
Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly
associated with insulin resistance (IR): obesity, type 2 diabetes mellitus, and
hypertriglyceridemia. We tested the hypotheses that (1) IR is an essential requirement for the
development of NASH and (2) a high association between IR and liver disease is relatively
specific for NASH. We measured body mass index (BMI), waist/hip ratio, and fasting serum
lipid, insulin, C-peptide, and glucose levels in 66 patients with NASH (21 with advanced …
associated with insulin resistance (IR): obesity, type 2 diabetes mellitus, and
hypertriglyceridemia. We tested the hypotheses that (1) IR is an essential requirement for the
development of NASH and (2) a high association between IR and liver disease is relatively
specific for NASH. We measured body mass index (BMI), waist/hip ratio, and fasting serum
lipid, insulin, C-peptide, and glucose levels in 66 patients with NASH (21 with advanced …