Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations
M Guzmán, J Castro - Biochimica et Biophysica Acta (BBA)-Lipids and Lipid …, 1989 - Elsevier
The sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA was increased
in mitochondria isolated from rat hepatocytes incubated with ethanol. This effect was
mimicked by incubation of hepatocytes with acetaldehyde or by preincubation of isolated
mitochondria with malonyl-CoA. Both ethanol and acetaldehyde increased the intracellular
concentration of malonyl-CoA. Results suggest that the ethanol-induced elevation of
intracellular malonyl-CoA levels may be responsible for the enhanced sensitivity of carnitine …
in mitochondria isolated from rat hepatocytes incubated with ethanol. This effect was
mimicked by incubation of hepatocytes with acetaldehyde or by preincubation of isolated
mitochondria with malonyl-CoA. Both ethanol and acetaldehyde increased the intracellular
concentration of malonyl-CoA. Results suggest that the ethanol-induced elevation of
intracellular malonyl-CoA levels may be responsible for the enhanced sensitivity of carnitine …