Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
Z Li, S Yang, H Lin, J Huang, PA Watkins, AB Moser… - Hepatology, 2003 - journals.lww.com
Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal
bacterial overgrowth and overexpress tumor necrosis factor α (TNF-α). In animal models for
alcoholic fatty liver disease (AFLD), decontaminating the intestine or inhibiting TNF-α
improves AFLD. Because AFLD and NAFLD may have a similar pathogenesis, treatment
with a probiotic (to modify the intestinal flora) or anti-TNF antibodies (to inhibit TNF-α activity)
may improve NAFLD in ob/ob mice. To evaluate this hypothesis, 48 ob/ob mice were given …
bacterial overgrowth and overexpress tumor necrosis factor α (TNF-α). In animal models for
alcoholic fatty liver disease (AFLD), decontaminating the intestine or inhibiting TNF-α
improves AFLD. Because AFLD and NAFLD may have a similar pathogenesis, treatment
with a probiotic (to modify the intestinal flora) or anti-TNF antibodies (to inhibit TNF-α activity)
may improve NAFLD in ob/ob mice. To evaluate this hypothesis, 48 ob/ob mice were given …