Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion
H Castrop, F Schweda, K Schumacher… - Journal of the …, 2001 - journals.lww.com
This study aimed to assess the role of cyclooxygenase-2 (COX-2)-derived prostanoids for
the macula densa control of renal afferent arteriolar resistance and for renin secretion. For
this purpose, studied were the effects of blocking macula densa salt transport by the loop
diuretic bumetanide (100 μM) on renal perfusate flow and on renin secretion in isolated
perfused rats, in which renocortical COX-2 expression was prestimulated in vivo by
treatment with the angiotensin-converting enzyme inhibitor ramipril, with low-salt diet, or with …
the macula densa control of renal afferent arteriolar resistance and for renin secretion. For
this purpose, studied were the effects of blocking macula densa salt transport by the loop
diuretic bumetanide (100 μM) on renal perfusate flow and on renin secretion in isolated
perfused rats, in which renocortical COX-2 expression was prestimulated in vivo by
treatment with the angiotensin-converting enzyme inhibitor ramipril, with low-salt diet, or with …