[HTML][HTML] Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia (∗)
T Sugaya, S Nishimatsu, K Tanimoto… - Journal of Biological …, 1995 - ASBMB
Angiotensin (AT) II, the bioactive octapeptide in the renin-angiotensin system that plays a
key role in cardiovascular homeostasis, exerts its multiple effects through the different types
of AT receptors, AT1a, AT1b, and AT2. Previously, we showed chronic hypotension in
angiotensinogen (the precursor of AT)-deficient mice and a dramatic increase in renin
mRNA levels in its kidney, but it remains unclear which types of AT receptors regulate the
blood pressure and renin gene expression. In order to elucidate the physiological roles of …
key role in cardiovascular homeostasis, exerts its multiple effects through the different types
of AT receptors, AT1a, AT1b, and AT2. Previously, we showed chronic hypotension in
angiotensinogen (the precursor of AT)-deficient mice and a dramatic increase in renin
mRNA levels in its kidney, but it remains unclear which types of AT receptors regulate the
blood pressure and renin gene expression. In order to elucidate the physiological roles of …