[HTML][HTML] Del1 induces integrin signaling and angiogenesis by ligation of αVβ3

K Penta, JA Varner, L Liaw, C Hidai… - Journal of Biological …, 1999 - ASBMB
Del1 is a novel extracellular matrix protein encoding three Notch-like epidermal growth
factor repeats, an RGD motif, and two discoidin domains. Del1 is expressed in an
endothelial cell-restricted pattern during early development. In studies reported here,
recombinant baculovirus Del1 protein was shown to promote αvβ3-dependent endothelial
cell attachment and migration. Attachment of endothelial cells to Del1 was associated with
clustering of αvβ3, the formation of focal complexes, and recruitment of talin and vinculin into …