[HTML][HTML] Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
JP Gratton, M Morales-Ruiz, Y Kureishi, D Fulton… - Journal of Biological …, 2001 - ASBMB
Vascular endothelial growth factor (VEGF) utilizes a phosphoinositide 3-kinase (PI 3-
kinase)/Akt signaling pathway to protect endothelial cells from apoptotic death. Here we
show that PI 3-kinase/Akt signaling promotes endothelial cell survival by inhibiting p38
mitogen-activated protein kinase (MAPK)-dependent apoptosis. Blockade of the PI 3-kinase
or Akt pathways in conjunction with serum withdrawal stimulates p38-dependent apoptosis.
Blockade of PI 3-kinase/Akt also led to enhanced VEGF activation of p38 and apoptosis. In …
kinase)/Akt signaling pathway to protect endothelial cells from apoptotic death. Here we
show that PI 3-kinase/Akt signaling promotes endothelial cell survival by inhibiting p38
mitogen-activated protein kinase (MAPK)-dependent apoptosis. Blockade of the PI 3-kinase
or Akt pathways in conjunction with serum withdrawal stimulates p38-dependent apoptosis.
Blockade of PI 3-kinase/Akt also led to enhanced VEGF activation of p38 and apoptosis. In …