Cross-presentation, dendritic cells, tolerance and immunity
WR Heath, FR Carbone - Annual review of immunology, 2001 - annualreviews.org
WR Heath, FR Carbone
Annual review of immunology, 2001•annualreviews.orgThis review examines the role of cross-presentation in tolerance and immunity. We discuss
(a) the antigenic requirements for cross-presentation,(b) the phenotype of the antigen
presenting cell (APC),(c) the cellular interactions and molecular signals involved in cross-
priming, and (d) the factors that direct the immune system toward tolerance or immunity. A
large part of this review is dedicated to summarizing our current knowledge of the cross-
presenting APC.
(a) the antigenic requirements for cross-presentation,(b) the phenotype of the antigen
presenting cell (APC),(c) the cellular interactions and molecular signals involved in cross-
priming, and (d) the factors that direct the immune system toward tolerance or immunity. A
large part of this review is dedicated to summarizing our current knowledge of the cross-
presenting APC.
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
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