[HTML][HTML] The Mechanism of Growth-inhibitory Effect of DOC-2/DAB2 in Prostate Cancer: CHARACTERIZATION OF A NOVEL GTPase-ACTIVATING PROTEIN …
Z Wang, CP Tseng, RC Pong, H Chen… - Journal of Biological …, 2002 - ASBMB
DOC-2/DAB2 is a member of the disable gene family with tumor-inhibitory activity. Its down-
regulation is associated with several neoplasms, and serine phosphorylation of its N
terminus modulates DOC-2/DAB2's inhibitory effect on AP-1 transcriptional activity. We
describe the cloning of DIP1/2, a novel gene that interacts with the N-terminal domain of
DOC-2/DAB2. DIP1/2 is a novel GTPase-activating protein containing a Ras GTPase-
activating protein homology domain (N terminus) and two other unique domains (ie 10 …
regulation is associated with several neoplasms, and serine phosphorylation of its N
terminus modulates DOC-2/DAB2's inhibitory effect on AP-1 transcriptional activity. We
describe the cloning of DIP1/2, a novel gene that interacts with the N-terminal domain of
DOC-2/DAB2. DIP1/2 is a novel GTPase-activating protein containing a Ras GTPase-
activating protein homology domain (N terminus) and two other unique domains (ie 10 …