Basement membrane (type IV) collagen
K Kühn - Matrix Biology, 1995 - Elsevier
K Kühn
Matrix Biology, 1995•ElsevierThe collagen IV molecule is 400 nm long and consists of two α1 (IV) and one α2 (IV) chains.
Their genes COL4A1 and COL4A2 form a transcription unit in which they are arranged head-
to-head and connected by a short common promoter region. Recently, four additional genes
have been discovered. They are similarly arranged in the pairs COL4A3–A4 and COL4A5–
A6 and code for additional collagen IV isoforms. In the macromolecular network of collagen
IV, which provides the scaffold for basement membranes, the molecules are attached and …
Their genes COL4A1 and COL4A2 form a transcription unit in which they are arranged head-
to-head and connected by a short common promoter region. Recently, four additional genes
have been discovered. They are similarly arranged in the pairs COL4A3–A4 and COL4A5–
A6 and code for additional collagen IV isoforms. In the macromolecular network of collagen
IV, which provides the scaffold for basement membranes, the molecules are attached and …
The collagen IV molecule is 400 nm long and consists of two α1(IV) and one α2(IV) chains. Their genes COL4A1 and COL4A2 form a transcription unit in which they are arranged head-to-head and connected by a short common promoter region. Recently, four additional genes have been discovered. They are similarly arranged in the pairs COL4A3–A4 and COL4A5–A6 and code for additional collagen IV isoforms. In the macromolecular network of collagen IV, which provides the scaffold for basement membranes, the molecules are attached and crosslinked via their like end-regions and they interact laterally with their triple-helical domains in a not yet fully understood manner. Collagen IV is involved in interactions with cells and possesses two specific recognition sites for the integrins α1β1 and α2β1.
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