Neuropeptide Y-induced angiogenesis in aging
J Kitlinska, EW Lee, S Movafagh, J Pons, Z Zukowska - Peptides, 2002 - Elsevier
Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and
aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays,
NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed
reduced expression (RT-PCR) of Y2 receptors and the NPY converting enzyme, dipeptidyl
peptidase IV (DPPIV), in spleens. Aging of human microvascular endothelial cells in vitro led
to a loss of their mitogenic responses to NPY accompanied by a lack of NPY receptor …
aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays,
NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed
reduced expression (RT-PCR) of Y2 receptors and the NPY converting enzyme, dipeptidyl
peptidase IV (DPPIV), in spleens. Aging of human microvascular endothelial cells in vitro led
to a loss of their mitogenic responses to NPY accompanied by a lack of NPY receptor …