[HTML][HTML] Hypoxia-associated induction of early growth response-1 gene expression
SF Yan, J Lu, YS Zou, J Soh-Won, DM Cohen… - Journal of Biological …, 1999 - ASBMB
The paradigm for the response to hypoxia is erythropoietin gene expression; activation of
hypoxia-inducible factor-1 (HIF-1) results in erythropoietin production. Previously, we found
that oxygen deprivation induced tissue factor, especially in mononuclear phagocytes, by an
early growth response (Egr-1)-dependent pathway without involvement of HIF-1 (Yan, S.-F.,
Zou, Y.-S., Gao, Y., Zhai, C., Mackman, N., Lee, S., Milbrandt, J., Pinsky, D., Kisiel, W., and
Stern, D.(1998) Proc. Natl. Acad. Sci. USA 95, 8298–8303). Now, we show that cultured …
hypoxia-inducible factor-1 (HIF-1) results in erythropoietin production. Previously, we found
that oxygen deprivation induced tissue factor, especially in mononuclear phagocytes, by an
early growth response (Egr-1)-dependent pathway without involvement of HIF-1 (Yan, S.-F.,
Zou, Y.-S., Gao, Y., Zhai, C., Mackman, N., Lee, S., Milbrandt, J., Pinsky, D., Kisiel, W., and
Stern, D.(1998) Proc. Natl. Acad. Sci. USA 95, 8298–8303). Now, we show that cultured …